Post doctoral, University of British Columbia (Donald E. Brooks, 2008-2013). 

    Ph.D. (Polymer of Chemistry and Physics), Jilin University, 2007. 

    B.Sc. (Fine Chemistry), Jilin Institute of Chemistry and Engineering, 1998. 

　　Our laboratory is utilizing polymer science in the development of synthetic universal biomembrane adhesive materials for application in delivery vehicles and other biomedical applications. For instance, polyvalent choline phosphate based polymers can fast adhesive to any cell membrane containing PC-lipids, and very fast uptake into the cytoplasm of cells, therefore it acts the carriers of local drug delivery to achieve efficient therapeutic targets. We hope that this system can avoid the host’s defense mechanisms and circulatory system of body. Our approach to developing biocompatible polymer is to increase dense choline phosphate in polymer chains, improving the bonding strength of the polyvalent choline phosphate based adhesive to cell surface, and derivatized with a huge range of chemical entities to allow their application as drug delivery vehicles and many others. We are applying these to areas as diverse as local tumor therapy model, tissue adhesion, medical imaging. 

　　[1]A Novel Local Delivery Platform Based on a pH and Thermo Sensitive Universal Reversible Biomembrane Adhesive,

　　Xifei Yu, Xiaoqiang Yang, Sonja Horte, Jayachandran N. Kizhakkedathu & Donald E. Brooks, Biomaterials, 2014, 35, 278

　　[2]A Thermoreversible Poly(Choline Phosphate) Based Universal Biomembrane Adhesive,

　　Xifei Yu, Xiaoqiang Yang, Sonja Horte, Jayachandran N. Kizhakkedathu & Donald E. Brooks, Macromolecular Bioscience, 2014, In Press

　　[3]Thermal Reversal of Polyvalent Choline Phosphate, a Multivalent Universal Biomembrane Adhesive,

　　Xifei Yu, Yuquan Zou, Sonja Horte, Johan Janzen, Jayachandran N. Kizhakkedathu & Donald E. Brooks, Biomacromolecules 2013, 14, 2611.

　　[4]ATRP Synthesis of Poly(2-(Methacryloyloxy)ethyl Choline Phosphate): a Multivalent Universal Biomembrane Adhesive,

　　Xifei Yu, Xiaoqiang Yang, Sonja Horte, Jayachandran N. Kizhakkedathu & Donald E. Brooks, Chem. Commun. 2013, 49, 6831.

　　[5]Polyvalent Choline Phosphate as a Universal Biomembrane Adhesive,

　　Xifei Yu, Zonghua Liu, Johan Janzen, Irina Chafeeva, Sonja Horte, Wei Chen, Rajesh K. Kainthan, Jayachandran N. Kizhakkedathu & Donald E. Brooks, Nat. Mater. 2012, 11, 468.

　　[6]Development of Soluble Ester-Linked Aldehyde Polymers for Proteomics,

　　Patrick Beaudette, Nicholas A. A. Rossi, Pitter F. Huesgen, Xifei Yu, Rajesh A. Shenoi, Alain Doucet, Christopher M. Overall & Jayachandran N. Kizhakkedathu, Anal. Chem. 2011, 83(17), 6500.

　　[7]Nucleation and Crystallization of H-shaped (PS)(2)PEG(PS)(2) Block Copolymers,

　　Yingying Pan, Xifei Yu, Tongfei Shi & Lijia An, Chinese Journal of Polymer Science 2010, 28(3), 347.

　　[8]Investigation of the Dewetting Inhibition Mechanism of Thin Polymer Films,

　　Lin Xu, Xifei Yu, Tongfie Shi & Lijia An, Soft Matterials 2009, 5(10), 2109.

　　[9]Dewetting of Linear Polymer/Star Polymer Blend Film,

　　Lin Xu, Xifei Yu, Tongfie Shi & Lijia An, Macromolecules 2008, 41(1), 21.

　　[10]Synthesis of Symmetric H-shaped Block Copolymer by the Combination of ATRP and Living Anionic Polymerization,

　　Xifei Yu, Guo Zhang, Tongfei Shi, Yanchun Han & Lijia An, Polymer 2007, 48(9), 2489.

　　[11]Synthesis of 王-Shaped Amphiphilic Block Copolymer by the Combination of ATRP and Living Anionic Polymerization,

　　Xifei Yu, Tongfei Shi, Lijia An, Guo Zhang & P.K. Dutta, J. Polym. Sci. Polym. Chem. 2007, 45, 147.

　　[12]Synthesis of Arms-6 Polystyrene by Atom Transformation Radical Polymerization,

　　Xifei Yu, Guo Zhang, Tongfei Shi & Lijia An, Acta Polymerica Sinica 2007, 6, 577.

　　[13]A self-Consistent Field Theory Study on the Morphologies of Linear ABCBA and H-shaped (AB)(2)C(BA)(2) Block Copolymers,

　　Xianggui Ye, Xifei Yu, Tongfei Shi, Zhaoyan Sun, Lijia An & Zhen Tong, Journal of Physical Chemistry B 2006, 110(46), 23578.

　　[14]Preparation and Characterization of Post-derivatives from Functional Polystyrene (ATRP) with p-nitroaniline-azomethine Phenol and Their Thermal and Optical Study,

　　Xifei Yu, Guo Zhang, Tongfei Shi, P.K. Dutta & Lijia An, e-Polymers 2006, No. 063.

　　[15]Comparing the Morphology and Phase Diagram of H-shaped ABC Block Copolymers and Linear ABC Block Copolymers,

　　Xianggui Ye, Xifei Yu, Zhaoyan Sun & Lijia An, Journal of Physical Chemistry B 2006, 110(24), 12042.

　　[16]Synthesis of Eight-Arm Polystyrene by Atom Transfer Radical Polymerization,

　　Xifei Yu, Guo Zhang, Tongfei Shi & Lijia An, Chemical Journal of Chinese Universities 2006, 27, 2435.

　　[17]Synthesis of Asymmetric H-shaped Block Copolymer by the Combination of Atom Transfer Radical Polymerization and Living Anionic Polymerization,

　　Xifei Yu, Tongfei Shi, Guo Zhang & Lijia An, Polymer 2006, 47(5), 1538.

　　[18]Abnormal blood clot formation induced by temperature responsive polymers by altered fibrin polymerization and platelet binding,

　　Benjamin F.L. Lai, Yuquan Zou, Xiaoqiang Yang, Xifei Yu, Jayachandran N. Kizhakkedathu, Biomaterials, 2014, 35(8), 2518.