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    ZnO-Functionalized Upconverting Nanotheranostic Agent: Multi-Modality Imaging-Guided Chemotherapy with On-Demand Drug Release Triggered by pH
    Author: englsh.ciac.cas.cn
    Update time: 2015-02-13
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    Limited therapeutic efficiency and severe side effects in patients are two major issues existing in current chemotherapy of cancers in clinic. To design a proper theranostic platform seems thus quite needed to target cancer cells accurately by bioimaging and simultaneously release drugs on demand without premature leakage. A novel ZnO-functionalized upconverting nanotheranostic platform has been fabricated for clear multi-modality bioimaging (upconversion luminescence (UCL), computed tomography (CT), and magnetic resonance imaging (MRI)) and specific pH-triggered on demand drug release. In a theranostic platform multimodality imaging provides much more detailed and exact information for cancer diagnosis than single-modality imaging. In addition, ZnO can play the role of a “gatekeeper” to efficiently block the drug in the mesopores of the as-prepared agents until it is dissolved in the acidic environment around tumors to realize sustained release of the drug. More importantly, the biodegradable ZnO, which is non-toxic against normal tissues, endows the as-prepared agents with high therapeutic effectiveness but very low side effects. These findings are of great interests and will inspire us much to develop novel effective imaging-guided on-demand chemotherapies in cancer treatment.

     
    The work was carried out by CIAC scientists, and the research findings have been published in Angew. Chem. Int. Ed. 2015, 54, 536 –540.

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